NCI Drug Dictionary

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The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.

A naturally occurring serine derivative diazo compound with antineoplastic properties, Azaserine functions as a purine antagonist and glutamine analogue (glutamine amidotransferase inhibitor) that competitively inhibits pathways in which glutamine is metabolized. An antibiotic and antitumor agent, Azaserine is used in clinical studies as a potential antineoplastic agent. Check for active clinical trials using this agent. (NCI Thesaurus)

Synonym:diazoacetate (ester) L-Serine
diazoacetic acid ester with serine
serine diazoacetate
Code name:CL-337
Chemical structure:
  • L-diazoacetate (ester) serine
  • L-serine diazoacetate (ester)
  • O-diazoacetyl-L-serine