NCI Dictionary of Cancer Terms

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The NCI Dictionary of Cancer Terms features 7,863 terms related to cancer and medicine.

Browse the dictionary by selecting a letter of the alphabet or by entering a cancer-related word or phrase in the search box.

A drug used to treat melanoma that cannot be removed by surgery or has spread to other parts of the body. It is also used as adjuvant therapy to treat melanoma in the skin and lymph nodes in patients who have already had surgery. MDX-010 is also being studied in the treatment of other types of cancer. MDX-010 binds to a substance called CTLA-4, which is found on T cells (a type of white blood cell). MDX-010 may block CTLA-4 and help the immune system kill cancer cells. It is a type of monoclonal antibody and a type of immune checkpoint inhibitor. Also called ipilimumab and Yervoy.