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Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Registry Information

Alternate Title

Phase II Pilot Study of Surgery and Adjuvant Intracavitary Photodynamic Therapy With Large Diffuser Fibers in Patients With Malignant Mesothelioma

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase II	Treatment	Closed	18 and over	NCI	RPCI-RP-9812 NCT00054002

Trial Description

Purpose:

Photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to kill cancer cells. Combining photodynamic therapy with surgery may be an effective treatment for malignant mesothelioma.

Phase II trial to study the effectiveness of combining photodynamic therapy with surgery in treating patients who have malignant mesothelioma.

Eligibility:

• At least 18 years old
• More than 1 month since chemotherapy
• No previous radiation therapy to the chest
• No previous radiation therapy for mesothelioma
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

Patients will receive an infusion of porfimer sodium on day 1. On day 3, they will undergo surgery to remove the tumor followed by photodynamic therapy. Patients will be evaluated at 1 month, every 4 months for 2 years, and every 6 months for 3 years.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

Roswell Park Cancer Institute

Todd Demmy, MD, Protocol chair		Ph: 716-845-5873; 800-685-6825

Registry Information
Official Title		Surgery and Intracavitary Photodynamic Therapy (PDT) for the Treatment of Malignant Pleural Mesothelioma; The Use of Light Delivery Fibers with Large Diffusers
Trial Start Date		1999-03-15
Registered in ClinicalTrials.gov		NCT00054002
Date Submitted to PDQ		2002-12-13
Information Last Verified		2006-12-11
NCI Grant/Contract Number		P30-CA16056

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