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Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Registry Information

Alternate Title

Phase III Randomized Study of Mediastinal Lymph Node Sampling Versus Complete Lymphadenectomy During Pulmonary Resection in Patients with N0 or N1 (Less Than Hilar) Non-Small Cell Lung Cancer

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase III	Treatment	Closed	18 and over	NCI	ACOSOG-Z0030 ACOSOG-Z0030, NCT00003831

Trial Description

Purpose:

Surgical removal of all lymph nodes in the chest may kill cancer cells that have spread from tumors in the lung. It is not yet known whether complete removal of all lymph nodes in the chest is more effective than removal of selected lymph nodes in treating patients who have stage I or stage II non-small cell lung cancer.

Randomized phase III trial to compare the effectiveness of complete removal of all lymph nodes in the chest with that of selected removal of lymph nodes during lung cancer surgery in treating patients who have stage I or stage II non-small cell lung cancer.

Eligibility:

• At least 18 years old
• No previous chemotherapy or radiation therapy for non-small cell lung cancer
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

Patients will have selected lymph nodes removed from the chest. Patients with negative lymph nodes will then be randomly assigned to one of two groups. Patients in group one will undergo surgery to remove tumors in the lung. Patients in group two will undergo surgery to remove nearly all the lymph nodes in the chest plus tumors in the lung. All patients will receive follow-up evaluations every 2-6 months for 2 years and once a year thereafter.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

American College of Surgeons Oncology Group

Mark Allen, MD, Protocol chair		Ph: 507-284-1517

Registry Information
Official Title		Randomized Trial of Mediastinal Lymph Node Sampling Versus Complete Lymphadenectomy During Pulmonary Resection in the Patient with N0 and N1 (Less Than Hilar) Non-Small Cell Carcinoma
Trial Start Date		1999-07-05
Registered in ClinicalTrials.gov		NCT00003831
Date Submitted to PDQ		1999-03-25
Information Last Verified		2003-07-30
NCI Grant/Contract Number		CA76001

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