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Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Registry Information

Alternate Title

Phase I Study of Paclitaxel and Cisplatin With Radiotherapy in Patients With Stage III or IV Endometrial Cancer

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
Phase I	Treatment	Completed	18 and over	NCI	GOG-9907 NCT00005840

Trial Description

Purpose:

Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.

This phase I trial is studying the side effects and best dose of combination chemotherapy when given with radiation therapy in treating patients with stage III or stage IV endometrial cancer.

Eligibility:

Eligibility criteria include the following:

• At least 18 years old
• No more than 8 weeks since surgery to remove the tumor
• Previous surgery to remove the uterus and ovaries
• No recurrent disease
• No previous chemotherapy or radiation therapy
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

Patients will receive an infusion of paclitaxel and cisplatin once a week for 6 weeks. They will also receive radiation therapy 5 days a week for 6 weeks. Patients will receive follow-up evaluations every 3 months for 2 years, every 6 months for 3 years, and then once a year thereafter.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

Gynecologic Oncology Group

D. Scott McMeekin, MD, Protocol chair		Ph: 405-271-8707

Registry Information
Official Title		Phase I Trial of the Treatment of Advanced Endometrial Cancer with Concurrent Weekly Paclitaxel and Cisplatin and Whole Abdominal Radiation Therapy
Trial Start Date		2000-07-17
Trial Completion Date		2009-07-17
Registered in ClinicalTrials.gov		NCT00005840
Date Submitted to PDQ		2000-04-07
Information Last Verified		2006-05-16
NCI Grant/Contract Number		CA27469

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