Questions About Cancer? 1-800-4-CANCER

Cervical Cancer Prevention (PDQ®)

Patient Version
Last Modified: 08/22/2013

Cervical Cancer Prevention



Avoiding risk factors and increasing protective factors may help prevent cancer.

Avoiding cancer risk factors may help prevent certain cancers. Risk factors include smoking, being overweight, and not getting enough exercise. Increasing protective factors such as quitting smoking, eating a healthy diet, and exercising may also help prevent some cancers. Talk to your doctor or other health care professional about how you might lower your risk of cancer.

The following risk factors increase the risk of cervical cancer:

HPV Infection

The most common cause of cervical cancer is infection of the cervix with human papillomavirus (HPV). There are more than 80 types of human papillomavirus. About 30 types can infect the cervix and about half of them have been linked to cervical cancer. HPV infection is common but only a very small number of women infected with HPV develop cervical cancer.

HPV infections that cause cervical cancer are spread mainly through sexual contact. Women who become sexually active at a young age and who have many sexual partners are at a greater risk of HPV infection and developing cervical cancer.

Smoking

Smoking cigarettes and breathing in secondhand smoke increase the risk of cervical cancer. Among women infected with HPV, dysplasia and invasive cancer occur 2 to 3 times more often in current and former smokers. Secondhand smoke causes a smaller increase in risk.

The following risk factors may increase the risk of cervical cancer:

High number of full-term pregnancies

Women who have had 7 or more full-term pregnancies may have an increased risk of cervical cancer.

Long-term use of oral contraceptives

Women who have used oral contraceptives ("the Pill") for 5 years or more have a greater risk of cervical cancer than women who have never used oral contraceptives. The risk is higher after 10 years of use.

The following protective factors may decrease the risk of cervical cancer:

Preventing HPV infection

HPV may be prevented by the following:

  • Avoiding sexual activity: HPV infection of the cervix is the most common cause of cervical cancer. Avoiding sexual activity decreases the risk of HPV infection.

  • Using barrier protection or spermicidal gels: Some methods used to prevent sexually transmitted diseases (STDs) decrease the risk of HPV infection. The use of barrier methods of birth control (such as a condom or gel that kills sperm) help protect against HPV infection.

  • Getting an HPV Vaccine: Two HPV vaccines have been approved by the U.S. Food and Drug Administration (FDA). The HPV vaccines have been shown to prevent infection with the two types of HPV that cause most cervical cancers. The vaccines protect against infection with these types of HPV for 6 to 8 years. It is not known if the protection lasts longer. The vaccines do not protect women who are already infected with HPV.

Screening

Regular pelvic exams and Pap tests help find abnormal cells in the cervix before cancer develops. However, test and procedures that may be used after an abnormal pelvic exam or Pap test result have risks. For example, the treatment of low-grade lesions may affect a woman's ability to become pregnant or carry a baby to full term. In women younger than 25 years, screening with the Pap test has more risks than benefits. Screening with the Pap test is not helpful in women older than 60 years who have had recent negative Pap tests. (See the PDQ summary on Cervical Cancer Screening for more information.)

The effect of diet on cervical cancer risk is not known.

Cancer prevention clinical trials are used to study ways to prevent cancer.

Cancer prevention clinical trials are used to study ways to lower the risk of developing certain types of cancer. Some cancer prevention trials are conducted with healthy people who have not had cancer but who have an increased risk for cancer. Other prevention trials are conducted with people who have had cancer and are trying to prevent another cancer of the same type or to lower their chance of developing a new type of cancer. Other trials are done with healthy volunteers who are not known to have any risk factors for cancer.

The purpose of some cancer prevention clinical trials is to find out whether actions people take can prevent cancer. These may include eating fruits and vegetables, exercising, quitting smoking, or taking certain medicines, vitamins, minerals, or food supplements.

New ways to prevent cervical cancer are being studied in clinical trials.

Clinical trials are taking place in many parts of the country. Information about clinical trials can be found in the Clinical Trials section of the NCI Web site. Check NCI's list of cancer clinical trials for cervical cancer prevention trials that are now accepting patients.