In English | En español
Questions About Cancer? 1-800-4-CANCER

Clinical Trial Results

Summaries of Newsworthy Clinical Trial Results < Back to Main
  • Posted: 06/08/2011

Page Options

  • Print This Page
  • Email This Document

Search Trial Results

Denosumab Effective for Multiple Myeloma and Solid Tumors

Adapted from the NCI Cancer Bulletin.

Results from a randomized phase III trial of denosumab for cancer were published online February 22, 2011, in the Journal of Clinical Oncology (JCO). FDA approval of denosumab for the reduction of skeletal-related events (SREs) was based in part on this study.

The nearly 1,800-patient trial had a design similar to that of a separate trial of denosumab for prostate cancer that was reported in The Lancet. It included patients with multiple myeloma and a variety of advanced solid tumors (but specifically excluded patients with prostate and breast cancer). Patients who received denosumab had a reduced risk of SREs compared with patients who received zoledronic acid, although the reduction did not reach statistical significance.

In an accompanying commentary, Howard West, M.D., of the Swedish Cancer Institute in Seattle addressed the economic implications of denosumab treatment, as well as a potential biomarker-driven approach to its use in patients with metastatic cancer.

This text may be reproduced or reused freely. Please credit the National Cancer Institute as the source. Any graphics may be owned by the artist or publisher who created them, and permission may be needed for their reuse.