UCSF study finds that metabolic profiles are essential for personalizing cancer therapy
NCI Cancer Center News
(Posted: 02/08/2012) - One way to tackle a tumor is to take aim at the metabolic reactions that fuel their growth. But a report in the February Cell Metabolism, a Cell Press Publication, shows that one metabolism-targeted cancer therapy will not fit all.

Ohio State study advances understanding of how early breast tumors become deadly
NCI Cancer Center News
(Posted: 02/08/2012) - Researchers have discovered a restricted pattern of molecules that differentiate early-stage breast tumors from invasive, life-threatening cancer. They also found a similar molecular signature that correlated with the aggressiveness of invasive tumors, and with the time to metastasis and overall survival.

Salk scientists use an old theory to discover new targets in the fight against breast cancer
NCI Cancer Center News
(Posted: 02/08/2012) - Reviving a theory first proposed in the late 1800s that the development of organs in the normal embryo and the development of cancers are related, scientists at the Salk Institute for Biological Studies have studied organ development in mice to unravel how breast cancers, and perhaps other cancers, develop in people. Their findings provide new ways to predict and personalize the diagnosis and treatment of cancer.

VCU/Old Dominion University study finds CD97 gene expression and function correlate with WT1 protein expression
NCI Cancer Center News
(Posted: 02/08/2012) - Researchers at Virginia Commonwealth University Medical Center's VCU Massey Cancer Center and Harold F. Young Neurosurgical Center (Richmond, VA) and Old Dominion University (Norfolk, VA) have discovered that suppression of Wilms tumor 1 protein (WT1) results in downregulation of CD97 gene expression in three glioblastoma cell lines and reduces the characteristic invasiveness exhibited by glial tumor cells.

Kimmel Cancer Center researchers find drugs targeting chromosomal instability may fight a particular breast cancer subtype
NCI Cancer Center News
(Posted: 02/07/2012) - A team of researchers at Jefferson's Kimmel Cancer Center has shown in a study published online Feb. 6 in the Journal of Clinical Investigation that the oncogene cyclin D1 may promote a genetic breakdown known as chromosomal instability (CIN). CIN is a known, yet poorly understood culprit in tumor progression.

Dana-Farber study shows that three 'targeted' cancer drugs raise risk of fatal side effects
NCI Cancer Center News
(Posted: 02/07/2012) - Treatment with three relatively new "targeted" cancer drugs has been linked to a slightly elevated chance of fatal side effects, according to a new analysis led by scientists at Dana-Farber Cancer Institute.

Researchers develop new technology to tackle treatment-resistant cancers
NCI Cancer Center News
(Posted: 02/06/2012) - Free-flowing cancer cells have been mapped with unprecedented accuracy in the bloodstream of patients with prostate, breast and pancreatic cancer, using a brand new approach, in an attempt to assess and control the disease as it spreads in real time through the body, and solve the problem of predicting response and resistance to therapies.

Northwestern University study finds soy isoflavone supplements did not provide breast cancer protections
NCI Cancer Center News
(Posted: 02/06/2012) - Soy isoflavone supplements did not decrease breast cancer cell proliferation in a randomized clinical trial, according to a study published in Cancer Prevention Research, a journal of the American Association for Cancer Research.