The RAS Initiative

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RAS Pathway Genes Now Available

All 180 RAS pathway genes are now available from the NCI RAS Initiative.

More than 30 percent of all human cancers – including 95 percent of pancreatic cancers and 45 percent of colorectal cancers — are driven by mutations of the RAS family of genes. NCI established the RAS initiative in 2013 to explore innovative approaches for attacking the proteins encoded by mutant forms of RAS genes and to ultimately create effective, new therapies for RAS-related cancers.

Message from Dr. Lowy

Dear Colleagues,

Portrait of Douglas Lowy

Douglas R. Lowy, M.D.
Acting Director, National Cancer Institute

NCI's RAS Initiative has come a long way since 2013, when former NCI director Dr. Harold Varmus and a group of experts envisioned a coordinated effort to understand the biology of RAS oncogenes. At that time, drugging RAS was a goal that had been all but abandoned by industry and many academic researchers, after years of trying. Today’s concerted effort, led by the RAS Initiative, is beginning to make headway.

I have a deeply personal interest in making Dr. Varmus’s vision succeed. For many years RAS was a primary focus of my lab, since the early days of RAS cloning when RAS genes were seemingly hiding in mouse retroviruses. It is highly gratifying to see the recent increased interest in the entire field of RAS biology—and the progress that is occurring—due to the RAS Initiative.

Our goal is to create a virtual network of scientists working collaboratively to solve the RAS problem. If you have not done so already, I encourage you to join our online forum RAS Central to share your challenges and ideas for solving the difficult and fascinating problem of oncogenic RAS.

Douglas R. Lowy, M.D.
Acting Director, National Cancer Institute

RAS Central

RAS Central is the RAS hub for blog posts, events and videos, and other useful tools and resources. Come to RAS Central to request RAS reagents to use in your research.

What’s Happening Now

RAS Lab Discussion Forum

RAS Lab is an online discussion forum to facilitate the exchange of scientific information among researchers in cancers related to RAS.

Tumor Microenvironment Influences Metabolism of Cancer Cells

In a new blog post in RAS Dialogue, Dr. Cosimo Commisso discusses how the metabolism of cancer cells might be different in different parts of solid tumors.