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Leukemia Steering Committee

The NCI Leukemia Steering Committee (LKSC) was established in 2009.

Mission Statement

The LKSC follows an efficient, cost-effective, science-driven, and transparent process to identify and promote the "Best Science" in clinical research on leukemia and related diseases by addressing the design and prioritization of phase 3 trials and large phase 2 studies.

Roster of Leukemia Steering Committee members

LKSC Activities

Clinical Trials Planning Meetings (CTPMs)

Clinical Trials

The following are clinical trials that were approved at the concept stage by the Steering Committee:

Trial ID NCT ID Trial Title
CALGB-11002 NCT01420926 A Randomized Phase II Trial of Decitabine-based Induction Strategies for Patients ≥ 60 Years Old with Acute Myeloid Leukemia
SWOG-1117 NCT01522976 A Randomized Phase II Study of Azacitidine in Combination With Lenalidomide (NSC-703813) vs. Azacitidine Alone vs. Azacititdine in Combination With Vorinostat (NSC-701852) for Higher-Risk Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML)
SWOG-1203 NCT01802333 A Randomized Phase III Study of Standard Cytarabine Plus Daunomycin (7+3) Therapy Versus Idarubicin with High Dose Cytarabine (IA) with or Without Vorinostat in Younger Patients with Previously Untreated Acute Myeloid Leukemia (AML)
ALLIANCE-A041202 NCT01886872 A Randomized Phase III Study of Chlorambucil Plus Rituximab Versus Ibrutinib Plus Rituximab Versus Ibrutinib Alone in Untreated Older Patients (>65 years of age) with Chronic Lymphocytic Leukemia (CLL)
ECOG-ACRIN-E1910 NCT02003222 A Phase III Randomized Trial of Blinatumomab for Newly Diagnosed BCR-ABL Negative B Acute Lymphoblastic Leukemia in Adults
ECOG-ACRIN-E1912 NCT02048813 A Randomized Phase II/III Study of (PCI-32765) Based-Therapy Versus Standard Fludarabine, Cyclophosphamide, and Rituximab (FCR) Chemoimmunotherapy in Untreated Younger Patients with Chronic Lymphocytic Leukemia (CLL)

Find all NCI-sponsored clinical trials.

CCCT Contact: Lawrence Baizer, Ph.D.