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Genetics of Endocrine and Neuroendocrine Neoplasias (PDQ®)

  • Updated: 07/17/2014

Table 6. American Thyroid Association Management Guidelines for MEN2A/FMTC and MEN2Ba

Syndrome  Age (y) Nodal Disease Basal Calcitonin (pg/mL)b Nodule ≥ 5mm  Lymph Node Dissection  Strength of Recommendationc 
MEN2A/FMTC<3–5No<40NoNoE
MEN2A/FMTC<3–5Yes>40YesYesB
MEN2A/FMTC>5No<40NoNoE
MEN2A/FMTC>5Yes>40YesYesB
MEN2B<1No<40NoNoE
MEN2B<1Yes>40YesYesB
MEN2B<1No<40NoYesC

FMTC = familial medullary thyroid carcinoma; MEN2 = multiple endocrine neoplasia type 2.
aAdapted from Kloos et al.[25]
bBasal calcitonin values are applicable in patients older than 6 months.
cBased on grading definitions established by the U.S. Preventive Services Task Force.

References

  1. Kloos RT, Eng C, Evans DB, et al.: Medullary thyroid cancer: management guidelines of the American Thyroid Association. Thyroid 19 (6): 565-612, 2009.  [PUBMED Abstract]