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Genetics of Prostate Cancer (PDQ®)

  • Posted: 11/20/2003
  • Updated: 11/10/2014

Table 1. Relative Risk (RR) Related to Family History of Prostate Cancera

Risk Group RR for Prostate Cancer (95% CI) 
Brother(s) with prostate cancer diagnosed at any age3.14 (2.37–4.15)
Father with prostate cancer diagnosed at any age2.35 (2.02–2.72)
One affected FDR diagnosed at any age2.48 (2.25–2.74)
Affected FDRs diagnosed <65 y2.87 (2.21–3.74)
Affected FDRs diagnosed ≥65 y1.92 (1.49–2.47)
Second-degree relatives diagnosed at any age2.52 (0.99–6.46)
Two or more affected FDRs diagnosed at any age4.39 (2.61–7.39)

CI = confidence interval; FDR = first-degree relative.
aAdapted from Kiciński et al.[21]


  1. Kiciński M, Vangronsveld J, Nawrot TS: An epidemiological reappraisal of the familial aggregation of prostate cancer: a meta-analysis. PLoS One 6 (10): e27130, 2011.  [PUBMED Abstract]