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Table 2. Proposed Prostate Cancer Susceptibility Loci

Gene Location Candidate Gene Clinical Testing Proposed Phenotype Comments 
HPC1 (OMIM)/RNASEL (OMIM) [12-34]1q25RNASEL Not availableYounger age at prostate cancer diagnosis (<65 y)Evidence of linkage is strongest in families with at least five affected persons, young age at diagnosis, and male-to-male transmission.
Higher tumor grade (Gleason score)
More advanced stage at diagnosisRNASEL mutations have been identified in a few 1q-linked families.
PCAP (OMIM) [1,9,16,23,35-44]1q42.2–43NoneNot availableYounger age at prostate cancer diagnosis (<65 y) and more aggressive diseaseEvidence of linkage is strongest in European families.
HPCX (OMIM) [33,39,45-51]Xq27–28NoneNot availableUnknownMay explain observation that an unaffected man with an affected brother has a higher risk than an unaffected man with an affected father.
CAPB (OMIM) [37,52-54]1p36NoneNot availableYounger age at prostate cancer diagnosis (<65 y)Strongest evidence of linkage was initially described in families with both prostate and brain cancer; follow-up studies indicate that this locus may be associated specifically with early-onset prostate cancer but not necessarily with brain cancer.
One or more cases of brain cancer
HPC20 (OMIM) [39,55-58]20q13NoneNot availableLater age at prostate cancer diagnosisEvidence of linkage is strongest in families with late age at diagnosis, fewer affected family members, and no male-to-male transmission.
No male-to-male transmission
8p [23,40,59-67]8p21–23MSR1 Not availableUnknownIn a genomic region commonly deleted in prostate cancer.
8q [44,68-85,85-87]8q24NoneNot availableMore aggressive diseaseData in some reports suggest that the population-attributable risk may be higher for African American men than for men of European origin.

References

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