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Genetics of Prostate Cancer (PDQ®)

  • Posted: 11/20/2003
  • Updated: 09/30/2014

Table 5. Prostate Cancer Susceptibility Loci Identified Through Genome-wide Association Studies (GWAS) in Men of Non-European Ancestry

SNP  Chromosomal Locus Nearest Known Gene Within 100 kb Region Study Citations  ORa 
African American Population
rs169019798q24NoneIntergenic[199]1.00–1.57
rs6983267Intergenic[199]0.83–2.43
rs7839365Intergenic[200]1.16–1.18
rs753228Intergenic[200]1.41–1.43
rs4871008Intergenic[200]1.15–1.19
rs1456315Intergenic[200]1.23–1.27
rs10098156Intergenic[200]1.26–1.30
rs6987409Intergenic[200]1.33–1.42
rs13282506Intergenic[200]1.25–1.28
rs7812429Intergenic[200]1.30–1.31
rs4313118Intergenic[200]1.16–1.17
rs1447295Intergenic[69]1.05
DG85737Intergenic[69]1.05
rs721010017q21ZNF652 Intronic[201]1.40–1.67
Chinese Population
rs8178269q31.2RAD23B-KLF4 Intergenic[202]1.33–1.43
rs10329419q13.4LILRA3 Intergenic[202]1.25–1.40
Japanese Population
rs20288982p11GGCX Intronic[203]0.96–1.22
rs133851912p24C2orf43 Intronic[204]1.12–1.22
rs20551093p11.2NoneIntergenic[203]1.15–1.33
rs26607533p12.1NoneIntergenic[205]1.42
rs126539465p15NoneIntergenic[204]1.23–1.31
rs19838916p21FOXP4 Intronic[204]1.11–1.23
rs3393316q22RFX6 and GPRC6AIntronic[204]1.18–1.22
rs132547388q24NoneIntergenic[205]1.59
rs6983561Intergenic[205]1.81
rs100090154Intergenic[205]1.41
rs225200410q26NoneIntergenic[203]1.12–1.23
rs193878111q12FAM111A Intergenic[203]1.11–1.25
rs960007913q22NoneIntergenic[204]1.17–1.19
rs443079617q12NoneIntronic[205]1.51

OR = odds ratio; SNP = single nucleotide polymorphism.
aORs are reported as a range across the various stages of GWAS discovery and validation when available.

References

  1. Freedman ML, Haiman CA, Patterson N, et al.: Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proc Natl Acad Sci U S A 103 (38): 14068-73, 2006.  [PUBMED Abstract]

  2. Okobia MN, Zmuda JM, Ferrell RE, et al.: Chromosome 8q24 variants are associated with prostate cancer risk in a high risk population of African ancestry. Prostate 71 (10): 1054-63, 2011.  [PUBMED Abstract]

  3. Haiman CA, Chen GK, Blot WJ, et al.: Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans. PLoS Genet 7 (5): e1001387, 2011.  [PUBMED Abstract]

  4. Haiman CA, Chen GK, Blot WJ, et al.: Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. Nat Genet 43 (6): 570-3, 2011.  [PUBMED Abstract]

  5. Xu J, Mo Z, Ye D, et al.: Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4. Nat Genet 44 (11): 1231-5, 2012.  [PUBMED Abstract]

  6. Akamatsu S, Takata R, Haiman CA, et al.: Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese. Nat Genet 44 (4): 426-9, S1, 2012.  [PUBMED Abstract]

  7. Takata R, Akamatsu S, Kubo M, et al.: Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. Nat Genet 42 (9): 751-4, 2010.  [PUBMED Abstract]

  8. Yamada H, Penney KL, Takahashi H, et al.: Replication of prostate cancer risk loci in a Japanese case-control association study. J Natl Cancer Inst 101 (19): 1330-6, 2009.  [PUBMED Abstract]