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Table 5. Summary of Cross-Sectional Studies of Anticipated Interest in Prostate Cancer Susceptibility Genetic Testing
|
Study Population
|
Sample Size
|
Percent Expressing Interest in Genetic Testing
|
Other Findings
|
| Prostate screening clinic participants [17] |
342 men aged 40 to 97 years |
89% |
28% did not demonstrate an understanding of the concept of inherited predisposition to cancer |
| General population; 9% with positive family history [8] |
12 focus groups with a total of 90 men aged 18 to 70 years |
All focus groups |
|
| African American men [18] |
320 men aged 21 to 98 years |
87% |
Most participants could not distinguish between genetic susceptibility testing and a prostate-specific antigen blood test |
| Men with and without first-degree male relatives with prostate cancer [9] |
126 men older than 40 years; mean age 52.6 years |
24% definitely; 50% probably |
|
| Swedish men with a FDR with prostate cancer [3] |
110 men aged 40 to 72 years |
76% definitely; 18% probably |
89% definitely or probably wanted their sons to undergo genetic testing |
| Sons of Swedish men with prostate cancer [10] |
101 men aged 21 to 65 years |
90%; 100% of sons with 2 to 3 family members affected with prostate cancer |
60% expressed worry about having an increased risk for prostate cancer |
| Healthy outpatient males with no history of prostate cancer [19] |
400 men aged 40 to 69 years |
82% |
|
| Healthy African American males with no history of prostate cancer [20] |
413 African American men aged 40 to 70 years |
87% |
Belief in the efficacy of and intention to undergo prostate cancer screening was associated with testing interest |
References
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Bratt O, Damber JE, Emanuelsson M, et al.: Risk perception, screening practice and interest in genetic testing among unaffected men in families with hereditary prostate cancer. Eur J Cancer 36 (2): 235-41, 2000.
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Doukas DJ, Fetters MD, Coyne JC, et al.: How men view genetic testing for prostate cancer risk: findings from focus groups. Clin Genet 58 (3): 169-76, 2000.
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Bratt O, Kristoffersson U, Lundgren R, et al.: Sons of men with prostate cancer: their attitudes regarding possible inheritance of prostate cancer, screening, and genetic testing. Urology 50 (3): 360-5, 1997.
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Myers RE, Hyslop T, Jennings-Dozier K, et al.: Intention to be tested for prostate cancer risk among African-American men. Cancer Epidemiol Biomarkers Prev 9 (12): 1323-8, 2000.
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