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Genetics of Prostate Cancer (PDQ®)

Health Professional Version
Last Modified: 02/18/2014

Changes to This Summary (02/18/2014)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Introduction

Updated statistics with estimated new prostate cancer cases and deaths for 2014 (cited American Cancer Society as reference 1).

Updated statistics with age-specific probabilities of being diagnosed with prostate cancer in 2014.

Identifying Genes and Inherited Variants Associated with Prostate Cancer Risk

Revised text to state that because a man’s lifetime risk of prostate cancer is one in seven, it is possible that families under study have men with both inherited and sporadic prostate cancer (cited American Cancer Society as reference 4).

Revised text to state that genome-wide searches have successfully identified susceptibility alleles for many complex diseases, including prostate cancer.

Revised text to state that to date, approximately 80 variants associated with prostate cancer have been identified by well-powered genome-wide association studies (GWAS) and validated in independent cohorts.

Added Eeles et al. as reference 187.

Added text to state that the association between risk and allele status for each variant listed in Table 4, Prostate Cancer Susceptibility Loci Identified Through GWAS in Men of European Ancestry, reached genome-wide statistical significance in more than one independent cohort.

Revised Table 4 to include an additional 40 variants that have been associated with prostate cancer.

Revised text to state that prostate cancer will affect an estimated one in seven American men during their lifetime (cited American Cancer Society as reference 3).

This summary is written and maintained by the PDQ Cancer Genetics Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.