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Genetics of Prostate Cancer (PDQ®)

Health Professional Version
Last Modified: 09/30/2014

Changes to This Summary (09/30/2014)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Identifying Genes and Inherited Variants Associated With Prostate Cancer Risk

Added text to state that additional insights are emerging regarding the potential interaction between single nucleotide polymorphisms (SNPs) identified from genome-wide association studies (GWAS) and prostate cancer susceptibility gene regulation. Also added text about a study that found that the T allele of a SNP at 6q22 enhanced binding of HOXB13, leading to allele-specific upregulation of RFX6, which correlates with prostate cancer progression and severity (cited Huang et al. as reference 218).

The Inherited Variants Associated With Prostate Cancer Aggressiveness subsection was comprehensively reviewed and extensively revised.

This summary is written and maintained by the PDQ Cancer Genetics Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.