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Breast Cancer Screening (PDQ®)

  • Updated: 10/31/2014

Table 2. Summary of Key Performance Measures for Screening with Tomosynthesis

Study [43] [44] [50] [51] [52] Overall 
CDR = cancer detection rate; DBT = digital breast tomosynthesis, also known as 3-D mammography; FFDM = full field digital mammography, also known as standard 2-D mammography; no. = number.
Study DesignProspective; each patient had both examsProspective; each patient had both examsHistorical control with 2-D onlyHistorical control with 2-D onlyHistorical control with 2-D only
No. of DBT12,6317,2929,499173,66323,149226,234
No. of FFDM12,6317,29213,856281,18754,684365,293
CDR 3-D+2-D8.0/1,0008.1/1,0005.37/1,0005.4/1,0006.3/1,000
CDR FFDM (2-D) Alone6.1/1,0005.3/1,0004.04/1,0004.2/1,0004.9/1,000
Difference (No. of Women)+1.9/1,000 (24)+2.7/1,000 (20)+1.3/1,000 (12)+1.2/1,000 (208)+1.4/1,000 (32)+1.3/1,000 (296)
P-Value (Detection Rate).001< .00010.18< .001.035
Absolute Recall Rate Difference-0.8%-2.0%-3.2%-1.6%-2.6%-1.8%
P-Value (Recall Rate)< .001< .0001< .001< .001> .0001

References

  1. Skaane P, Bandos AI, Gullien R, et al.: Prospective trial comparing full-field digital mammography (FFDM) versus combined FFDM and tomosynthesis in a population-based screening programme using independent double reading with arbitration. Eur Radiol 23 (8): 2061-71, 2013.  [PUBMED Abstract]

  2. Ciatto S, Houssami N, Bernardi D, et al.: Integration of 3D digital mammography with tomosynthesis for population breast-cancer screening (STORM): a prospective comparison study. Lancet Oncol 14 (7): 583-9, 2013.  [PUBMED Abstract]

  3. Rose SL, Tidwell AL, Bujnoch LJ, et al.: Implementation of breast tomosynthesis in a routine screening practice: an observational study. AJR Am J Roentgenol 200 (6): 1401-8, 2013.  [PUBMED Abstract]

  4. Friedewald SM, Rafferty EA, Rose SL, et al.: Breast cancer screening using tomosynthesis in combination with digital mammography. JAMA 311 (24): 2499-507, 2014.  [PUBMED Abstract]

  5. Greenberg JS, Javitt MC, Katzen J, et al.: Clinical performance metrics of 3D digital breast tomosynthesis compared with 2D digital mammography for breast cancer screening in community practice. AJR Am J Roentgenol 203 (3): 687-93, 2014.  [PUBMED Abstract]