Changes to This Summary (05/23/2013)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Revised text to state that while these results are promising, there were problems, including the following: the results varied in different publications; the comparison group was not actively followed; the confidence interval was near 1.0; intention-to-treat analysis was not used; assessment of outcome was not blinded; and generalizability to other populations is uncertain (cited Aghoram et al. as reference 14).
Added text about a review that concluded the method of measuring alpha-fetoprotein was not sensitive enough to detect hepatocellular carcinoma, affecting the interpretation of negative results.
This summary is written and maintained by the PDQ Screening and Prevention Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.