Questions About Cancer? 1-800-4-CANCER
  • Print
  • email
  • Facebook
  • Twitter
  • Google+
  • Pinterest

Table 10. Summary of Magnetic Resonance Imaging (MRI) Screening Studies in Women at Hereditary Risk of Breast Cancer

Series Rijnsburger [38] Warner [33] MARIBS [32] Kuhl [36] Weinstein [39] Sardanelli [40] Totals 
N PatientsOverall2,1572366496876095014,839
BRCA1/BRCA2 Carriers59423612065443301,389
N Screening Episodes6,2534571,8811,6791,59211,862
N CancersBaseline22a1320100065
In situ 199697858
Annual Incidence10.4/1,00019/1,000
Detected at Planned Screening782133271849226 (83%)
N Detected by Each ModalityMammography31c814972594 (42%)
MRI51c1727251242174 (77%)
Ultrasoundd71032646 (41%)
Follow-upMedian of 4.9 yMinimum of 1 y2–7 yMedian of 29.09 mo2 y3 y

aBased on the first 1,909 women screened.[30]
bIncludes patients with invasive cancer only and patients with both invasive and in situ cancers.
cIncludes only 75 cancers detected in women who underwent both mammographic and MRI screening.
dRestricted to studies in which ultrasound was performed.


  1. Kriege M, Brekelmans CT, Boetes C, et al.: Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med 351 (5): 427-37, 2004.  [PUBMED Abstract]

  2. Leach MO, Boggis CR, Dixon AK, et al.: Screening with magnetic resonance imaging and mammography of a UK population at high familial risk of breast cancer: a prospective multicentre cohort study (MARIBS). Lancet 365 (9473): 1769-78, 2005 May 21-27.  [PUBMED Abstract]

  3. Warner E, Plewes DB, Hill KA, et al.: Surveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography, and clinical breast examination. JAMA 292 (11): 1317-25, 2004.  [PUBMED Abstract]

  4. Kuhl C, Weigel S, Schrading S, et al.: Prospective multicenter cohort study to refine management recommendations for women at elevated familial risk of breast cancer: the EVA trial. J Clin Oncol 28 (9): 1450-7, 2010.  [PUBMED Abstract]

  5. Rijnsburger AJ, Obdeijn IM, Kaas R, et al.: BRCA1-associated breast cancers present differently from BRCA2-associated and familial cases: long-term follow-up of the Dutch MRISC Screening Study. J Clin Oncol 28 (36): 5265-73, 2010.  [PUBMED Abstract]

  6. Weinstein SP, Localio AR, Conant EF, et al.: Multimodality screening of high-risk women: a prospective cohort study. J Clin Oncol 27 (36): 6124-8, 2009.  [PUBMED Abstract]

  7. Sardanelli F, Podo F, Santoro F, et al.: Multicenter surveillance of women at high genetic breast cancer risk using mammography, ultrasonography, and contrast-enhanced magnetic resonance imaging (the high breast cancer risk italian 1 study): final results. Invest Radiol 46 (2): 94-105, 2011.  [PUBMED Abstract]