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Table 12. Available Clinical Practice Guidelines for Hereditary Breast and Ovarian Cancer (HBOC)

Organization Risk Assessment and Genetic Counseling Recommendations Genetic Testing Recommendations Management Recommendations 
ACOG (2009) [322]Risk Assessment: AddressedNot addressedAddressed
Genetic Counseling: Addressed
ASCO (2010) [4]Risk Assessment: General recommendations; not specific to HBOCGeneral recommendations; not specific to HBOCNot addressed
Genetic Counseling: Addressed
NAPBC (2013) [323]Risk Assessment: Refers to other published guidelinesIndications for testing not addressed; components of pretest and posttest counseling addressedNot addressed
Genetic Counseling: Addressed
NSGC (2013) [324]Risk Assessment: Refers to other published guidelines and available modelsAddressedRefers to other published guidelines
Genetic Counseling: Addressed
NCCN (2014) [3]Risk Assessment: AddressedAddressedAddressed
Genetic Counseling: Addressed
SGO (2014) [325]Risk Assessment: AddressedAddressedAddressed in general terms
Genetic Counseling: Addressed
USPSTFa (2014) [326]Risk Assessment: AddressedAddressed in general terms and other guidelines referencedAddressed in general terms and other guidelines referenced
Genetic Counseling: Addressed

ACOG = American College of Obstetricians and Gynecologists; ASCO = American Society of Clinical Oncology; NAPBC = National Accreditation Program for Breast Centers; NCCN = National Comprehensive Cancer Network; NSGC = National Society of Genetic Counselors; SGO = Society of Gynecologic Oncology; USPSTF = U.S. Preventive Services Task Force.
aThe USPSTF guidelines apply to individuals without a prior cancer diagnosis.


  1. National Comprehensive Cancer Network: NCCN Clinical Practice Guidelines in Oncology: Genetic/Familial High-Risk Assessment: Breast and Ovarian. Version 1.2014. Rockledge, PA: National Comprehensive Cancer Network, 2014. Available online with free registration. Last accessed June 17, 2014. 

  2. Robson ME, Storm CD, Weitzel J, et al.: American Society of Clinical Oncology policy statement update: genetic and genomic testing for cancer susceptibility. J Clin Oncol 28 (5): 893-901, 2010.  [PUBMED Abstract]

  3. American College of Obstetricians and Gynecologists, ACOG Committee on Practice Bulletins--Gynecology, ACOG Committee on Genetics, et al.: ACOG Practice Bulletin No. 103: Hereditary breast and ovarian cancer syndrome. Obstet Gynecol 113 (4): 957-66, 2009.  [PUBMED Abstract]

  4. National Accreditation Program for Breast Centers: 2013 Breast Center Standards Manual. Chicago, IL: National Accreditation Program for Breast Centers, 2013. Available online. Last accessed April 15, 2014. 

  5. Berliner JL, Fay AM, Cummings SA, et al.: NSGC practice guideline: risk assessment and genetic counseling for hereditary breast and ovarian cancer. J Genet Couns 22 (2): 155-63, 2013.  [PUBMED Abstract]

  6. Society of Gynecologic Oncology: SGO Clinical Practice Statement: Genetic Testing for Ovarian Cancer. 2014. Available online. Last accessed April 15, 2014. 

  7. Moyer VA; U.S. Preventive Services Task Force: Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer in women: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 160 (4): 271-81, 2014.  [PUBMED Abstract]