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Genetics of Breast and Ovarian Cancer (PDQ®)

  • Updated: 07/11/2014

Table 4. Estimated Cumulative Breast and Ovarian Cancer Risks in BRCA1 and BRCA2 Mutation Carriers

Study Breast cancer risk (%) by age 70 y (95% CI)  Ovarian cancer risk (%) by age 70 y (95% CI)  
CI = confidence interval.
BRCA1 BRCA2 BRCA1 BRCA2
Antoniou et al. (2003) [114]65 (44–78)45 (31–56)39 (18–54)11 (2.4–19)
Chen et al. (2007) [115]55 (50–59)47 (42–51)39 (34–45)17 (13–21)

References

  1. Antoniou A, Pharoah PD, Narod S, et al.: Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 72 (5): 1117-30, 2003.  [PUBMED Abstract]

  2. Chen S, Parmigiani G: Meta-analysis of BRCA1 and BRCA2 penetrance. J Clin Oncol 25 (11): 1329-33, 2007.  [PUBMED Abstract]