 |
|
|
Table 6. High-probability breast cancer susceptibility loci for sporadic breast cancer identified through genome-wide association studies
|
Putative Gene(s)
|
Chromosome
|
SNP(s)
|
Study Citations*
|
|
* Initial study that provided convincing evidence for each locus.
|
|
FGFR2
|
10q26.13 |
rs2981582 |
[64] |
|
TOX3
|
16q12.1 |
rs3803662 |
[64] |
|
MAP3K1
|
5q11.2 |
rs889312 |
[64] |
|
Intergenic
|
8q24.21 |
rs13281615 |
[64] |
|
LSP1
|
11p15.5 |
rs3817198 |
[64] |
|
Intergenic
|
2q35 |
rs13387042 |
[65] |
|
ESR1
|
6q25.1 |
rs2046210 |
[68] |
|
MRPS30
|
5p12 |
rs10941679 |
[71] |
|
Intergenic
|
1p11.2 |
rs11249433 |
[73] |
|
RAD51B
|
14q24.1 |
rs999737 |
[73] |
|
SLC4A7,NEK10 |
3p24 |
rs4973786 |
[72] |
|
COX11
|
17q23.2 |
rs6504950 |
[72] |
References
-
Easton DF, Pooley KA, Dunning AM, et al.: Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447 (7148): 1087-93, 2007.
[PUBMED Abstract]
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Stacey SN, Manolescu A, Sulem P, et al.: Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet 39 (7): 865-9, 2007.
[PUBMED Abstract]
-
Zheng W, Long J, Gao YT, et al.: Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nat Genet 41 (3): 324-8, 2009.
[PUBMED Abstract]
-
Stacey SN, Manolescu A, Sulem P, et al.: Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet 40 (6): 703-6, 2008.
[PUBMED Abstract]
-
Ahmed S, Thomas G, Ghoussaini M, et al.: Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet 41 (5): 585-90, 2009.
[PUBMED Abstract]
-
Thomas G, Jacobs KB, Kraft P, et al.: A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet 41 (5): 579-84, 2009.
[PUBMED Abstract]
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