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Table 7. Cumulative Cancer Risks in Peutz-Jeghers Syndrome Up To Specified Agea

Site Age (y) Cumulative Risk (%)b Reference(s) 
Any cancer60–7037–93[358-361,365,366]
GI cancerc,d60–7038–66[360,361,365,366]
Gynecological cancer60–7013–18[360,361]
Per origin
Small bowel6513[359]

GI = gastrointestinal.
aReprinted with permission from Macmillan Publishers Ltd: Gastroenterology [362], copyright 2010.
bAll cumulative risks were increased compared with the general population (P < .05), with the exception of cervix and testes.
cGI cancers include colorectal, small intestinal, gastric, esophageal, and pancreatic.
dWesterman et al.: GI cancer does not include pancreatic cancer.[365]
eDid not include adenoma malignum of the cervix or Sertoli cell tumors of the testes.


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