In English | En español
Questions About Cancer? 1-800-4-CANCER

Genetics of Skin Cancer (PDQ®)

  • Last Modified: 11/10/2014

Page Options

  • Print This Page
  • Print This Document
  • View Entire Document
  • Email This Document

Changes to This Summary (11/10/2014)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Melanoma

Added text to state that population-based studies of more than 238,000 first-degree relatives of 23,000 melanoma patients found a lifetime cumulative risk of melanoma of 2.5% to 3%, which is about double the risk of the general population; when two or more family members were diagnosed with melanoma before age 30 years, the lifetime cumulative risk for the family members rose to 14% (cited Fallah et al. as reference 60).

Revised text to state that two genome-wide linkage studies of 35 and 42 Swedish families identified evidence of linkage on chromosomal regions 3p29, 17p11-12, and 18q22 (cited Tuominen et al. as reference 136).

Added text to state that a study that analyzed different MC1R variants from more than 1,600 melanoma cases stratified by type of melanoma found an association between the R163Q variant and lentigo maligna melanoma that was independent of pigmentary effects (cited Puig-Butillé et al. as reference 145).

This summary is written and maintained by the PDQ Cancer Genetics Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.