Changes to This Summary (10/28/2013)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
The Squamous Cell Carcinoma section was comprehensively reviewed and extensively revised.
Added text to state that the frequency of CDKN2A mutations is as high as 22% in families with two cases of melanoma who have other features of hereditary melanoma (cited Maubec et al. as reference 74).
Revised text to state that some families with CDKN2A mutations may have a pattern of site-specific pancreatic cancer only (cited Harinck et al. as reference 101).
Added BRCA2 as a new subsection.
Added Bränström et al. as reference 1.
Revised text to state that the most important predictors of distress included a personal history of melanoma, having concerns about the impact of melanoma on family, having a high information-seeking disposition, a perceived importance of sun exposure in causing melanoma, and not having children.
Added text about a randomized controlled trial of 73 adults with a family history of melanoma who were randomly assigned to receive either genetic counseling with genotyping results or usual care (cited Glanz et al. as reference 15).
Added Shuk et al. as a reference 16.
Added text a study that examined intentions to receive a physician skin examination and to perform a skin self-examination among first-degree relatives of individuals diagnosed with melanoma who had not recently engaged in skin surveillance (cited Coups et al. as reference 24).
This summary is written and maintained by the PDQ Cancer Genetics Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.