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Adult Non-Hodgkin Lymphoma Treatment (PDQ®)

  • Updated: 11/21/2014

Table 4. Standard Treatment Options for NHL

Stage Standard Treatment Options 
CNS = central nervous system; CHOP = cyclophosphamide, doxorubicin, vincristine, and prednisone; IF-XRT = involved-field radiation therapy; NHL = non-Hodgkin lymphoma; R-CHOP = rituximab, an anti-CD20 monoclonal antibody, cyclophosphamide, doxorubicin, vincristine, and prednisone.
Indolent, Stage I and Contiguous Stage II Adult NHLRadiation therapy
Rituximab with or without chemotherapy
Watchful waiting
Other therapies as designated for patients with advanced-stage disease
Indolent, Noncontiguous Stage II/III/IV Adult NHLWatchful waiting for asymptomatic patients
Rituximab
Purine nucleoside analogs
Alkylating agents (with or without steroids)
Combination chemotherapy
Yttrium-90–labeled ibritumomab tiuxetan
Maintenance rituximab
Indolent, Recurrent Adult NHLChemotherapy (single agent or combination)
Rituximab
Lenalidomide
Radiolabeled anti-CD20 monoclonal antibodies
Palliative radiation therapy
Aggressive, Stage I and Contiguous Stage II Adult NHLR-CHOP with or without IF-XRT
Aggressive, Noncontiguous Stage II/III/IV Adult NHLR-CHOP
Other combination chemotherapy
Adult Lymphoblastic LymphomaIntensive therapy
Radiation therapy
Diffuse, Small, Noncleaved-Cell/Burkitt LymphomaAggressive multidrug regimens
Central nervous system (CNS) prophylaxis
Aggressive, Recurrent Adult NHLBone marrow or stem cell transplantation
Re-treatment with standard agents
Palliative radiation therapy