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Childhood Astrocytomas Treatment (PDQ®)

  • Posted: 08/21/2009
  • Updated: 06/20/2014

Table 2. Histologic Grade of Childhood Astrocytomas and Other Tumors of Glial Origin

Type WHO Histologic Grade 
aIn 2007, the WHO further categorized astrocytomas, oligodendroglial tumors, and mixed gliomas according to histopathologic features and biologic behavior. It was determined that the pilomyxoid variant of pilocytic astrocytoma may be an aggressive variant that is more likely to disseminate, and it was reclassified as a grade II tumor.[1,2,5]
Astrocytic Tumors:
Pilocytic astrocytomaI
Pilomyxoid astrocytomaaII
Pleomorphic xanthoastrocytomaII
Subependymal giant cell astrocytomaI
Diffuse astrocytoma:
Gemistocytic astrocytomaII
Protoplasmic astrocytomaII
Fibrillary astrocytomaII
Anaplastic astrocytomaIII
GlioblastomaIV
Oligodendroglial Tumors:
OligodendrogliomaII
Anaplastic oligodendrogliomaIII
Mixed Gliomas:
OligoastrocytomaII
Anaplastic oligoastrocytomaIII

References

  1. Louis DN, Ohgaki H, Wiestler OD, et al., eds.: WHO Classification of Tumours of the Central Nervous System. 4th ed. Lyon, France: IARC Press, 2007. 

  2. Louis DN, Ohgaki H, Wiestler OD, et al.: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114 (2): 97-109, 2007.  [PUBMED Abstract]

  3. Komotar RJ, Burger PC, Carson BS, et al.: Pilocytic and pilomyxoid hypothalamic/chiasmatic astrocytomas. Neurosurgery 54 (1): 72-9; discussion 79-80, 2004.  [PUBMED Abstract]