Late Effects in Patients Treated for Childhood Craniopharyngioma
Quality-of-life issues are important in this group of patients and are difficult to generalize due to various treatment modalities. Whereas intelligence quotient is usually maintained, behavioral issues and memory deficits attributed to the frontal lobe and hypothalamus are common. Patients with hypothalamic involvement showed impairment in memory and executive functioning. Other common problems include visual loss, obesity (which can be life threatening), and the almost universal need for life-long endocrine replacement with multiple pituitary hormones.[4-6][Level of evidence: 3iiiC] Vasculopathies and secondary tumors may also result from local irradiation. A recent report indicated that adults on long-term growth hormone replacement secondary to childhood craniopharyngioma involving the hypothalamus were at increased cardiovascular risk.
Refer to the PDQ summary on Late Effects of Treatment for Childhood Cancer for specific information about the incidence, type, and monitoring of late effects in childhood and adolescent cancer survivors.
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