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Childhood Central Nervous System Germ Cell Tumors Treatment (PDQ®)

  • Posted: 12/14/2011
  • Updated: 08/01/2013

Table 1. Immunohistochemical Markers

Tumor Type Beta-HCG AFP PLAP c-kit 
AFP = alpha-fetoprotein; HCG = human chorionic gonadotropin; PLAP = placental alkaline phosphatase.
Choriocarcinoma+-±-
Embryonal carcinoma--+-
Germinoma (syncytiotrophoblastic)+-±+
Immature teratoma±±-±
Mature teratoma----
Mixed germ cell tumor±±±±
Pure germinoma--±+
Yolk sac tumor-+±-