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Childhood Central Nervous System Germ Cell Tumors Treatment (PDQ®)

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Changes to This Summary (04/09/2015)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Treatment Option Overview for Childhood CNS Germ Cell Tumors

Revised text to state that patients with localized germinomas are effectively treated with whole-ventricular irradiation supplemented with tumor site–boost radiation therapy; focal irradiation to the tumor bed, regardless of response to chemotherapy, is considered inadequate treatment (cited Joo et al. as reference 6).

Revised Table 4 to state that chemotherapy followed by radiation therapy is a treatment option for newly diagnosed childhood nongerminomatous germ cell tumors (NGGCTs).

Treatment of Newly Diagnosed Childhood Germinomas

Added Joo et al. as reference 6.

Treatment of Newly Diagnosed Childhood Nongerminomatous Germ Cell Tumors

Revised text to state that chemotherapy followed by radiation therapy is a treatment option for newly diagnosed childhood NGGCTs.

Revised text to state that surgery, for tumors that do not respond to treatment or for tumors that increase in size after therapy (possible growing teratoma syndrome), is an adjuvant treatment option for newly diagnosed childhood NGGCTs.

Revised text to state that some investigators have proposed radiation therapy fields that are smaller than craniospinal irradiation (e.g., whole ventricular with boost radiation therapy to the local tumor site) for nondisseminated NGGCT patients.

Long-Term Effects of Childhood CNS Germ Cell Tumors

Added Liang et al. as reference 7.

This summary is written and maintained by the PDQ Pediatric Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.

  • Updated: April 9, 2015