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Childhood Central Nervous System Germ Cell Tumors Treatment (PDQ®)

Health Professional Version
Last Modified: 08/01/2013

Treatment Option Overview

Teratomas, germinomas, and nongerminomatous germ cell tumors (NGGCTs) have differing prognoses and may require different treatment regimens. For older children (aged >3 years) and adults, radiation therapy has been an important component of therapy for germinomas and NGGCTs, although the total dose and fields are debated. The addition of chemotherapy has shown central nervous system GCTs to be chemotherapy sensitive. Regimens that utilize both chemotherapy and radiation therapy have been investigated for germinomas and NGGCTs. These combined regimens have been adopted to increase survival (NGGCTs) or to allow for reduction in the field or dose of radiation therapy (germinomas and NGGCTs).[1-4]

  1. Osuka S, Tsuboi K, Takano S, et al.: Long-term outcome of patients with intracranial germinoma. J Neurooncol 83 (1): 71-9, 2007.  [PUBMED Abstract]

  2. Allen JC, Kim JH, Packer RJ: Neoadjuvant chemotherapy for newly diagnosed germ-cell tumors of the central nervous system. J Neurosurg 67 (1): 65-70, 1987.  [PUBMED Abstract]

  3. Kellie SJ, Boyce H, Dunkel IJ, et al.: Primary chemotherapy for intracranial nongerminomatous germ cell tumors: results of the second international CNS germ cell study group protocol. J Clin Oncol 22 (5): 846-53, 2004.  [PUBMED Abstract]

  4. Robertson PL, DaRosso RC, Allen JC: Improved prognosis of intracranial non-germinoma germ cell tumors with multimodality therapy. J Neurooncol 32 (1): 71-80, 1997.  [PUBMED Abstract]