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Childhood Central Nervous System Germ Cell Tumors Treatment (PDQ®)

  • Last Modified: 08/01/2013

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Treatment of Newly Diagnosed Teratomas

Teratomas are designated as mature or immature based on the absence or presence of differentiated tissues. The Japanese Pediatric Brain Tumor Study Group stratifies teratomas for classification and intensity of treatment (chemotherapy and radiation) for mature versus immature into the good- and intermediate-risk groups, respectively (see Table 3), while the Children’s Oncology Group includes immature teratomas with other NGGCTs.

The treatment for teratomas should include maximal surgical resection. Adjuvant treatment in the form of focal radiation therapy and/or adjuvant chemotherapy for subtotally resected tumors is controversial, with small institutional series suggesting potential utility for the use of radiosurgery (stereotactic radiosurgery).[1,2][Level of evidence: 3iA]

References
  1. Huang X, Zhang R, Zhou LF: Diagnosis and treatment of intracranial immature teratoma. Pediatr Neurosurg 45 (5): 354-60, 2009.  [PUBMED Abstract]

  2. Lee YH, Park EK, Park YS, et al.: Treatment and outcomes of primary intracranial teratoma. Childs Nerv Syst 25 (12): 1581-7, 2009.  [PUBMED Abstract]