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Table 2. Surveillance Testing During and After Treatment Used in Prospective Clinical Trials

Surveillance Period  Frequency of Visits During Surveillance Period Testing 
First 3 years after diagnosisEvery 3 monthsPhysical exam
Imaging of the brain and spine every 3 months for the first two years; after year 2, imaging of the spine can be performed every 6 months
Endocrinology evaluation once a year
Neuropsychologic testing every 1–2 years
3–5 years after diagnosisEvery 6 monthsPhysical exam
Imaging of the brain and spine once a year
Endocrinology evaluation once a year
Neuropsychologic testing every 1–2 years
More than 5 years after diagnosisOnce a yearPhysical exam
Imaging of the brain once a year
Endocrinology evaluation once a year
Neuropsychologic testing every 1–2 years (optional)