Changes to This Summary (05/20/2011)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Added text to state that in contrast, gains of 9, 15q, and 18, and loss of chromosome 6 were associated with improved prognosis (cited Korshunov et al. as reference 11).
Histopathologic Classification of Childhood Ependymal Tumors
Added text to state that in children, approximately 65% to 75% of ependymomas arise in the posterior fossa; believed to arise from radial glia cells, supratentorial and infratentorial ependymomas have different genomic, gene expression, and immunohistochemical signatures; supratentorial tumors are characterized by neuronal differentiation (cited Taylor et al. and Andreiuolo et al. as references 2 and 3, respectively).
Treatment of Recurrent Childhood Ependymoma
Added text to state that regardless of treatment strategy, the prognosis for patients with recurrence is poor (cited Zacharoulis et al. and Kano et al. as references 1 and 7, respectively and level of evidence 3iiiA).
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