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Endometrial Cancer Treatment (PDQ®)

Stage Information for Endometrial Cancer

Definitions: FIGO

The Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) and the American Joint Committee on Cancer (AJCC) have designated staging to define endometrial cancer; the FIGO system is most commonly used.[1,2]

Carcinosarcomas should be staged as carcinoma.[2] FIGO stages are further subdivided by the histologic grade of the tumor, for example, stage IC G2.

Table 1. Cancer of the Corpus Uteria
FIGO Stage Description
aAdapted from FIGO Committee on Gynecologic Oncology.[1]
bEither G1, G2, or G3 (G = grade).
cEndocervical glandular involvement only should be considered as stage I and no longer as stage II.
dPositive cytology has to be reported separately without changing the stage.
Ib Tumor confined to the corpus uteri.
IAb No or less than half myometrial invasion.
IBb Invasion equal to or more than half of the myometrium.
IIb Tumor invades cervical stroma but does not extend beyond the uterus.c
IIIb Local and/or regional spread of the tumor.
IIIAb Tumor invades the serosa of the corpus uteri and/or adnexae.d
IIIBb Vaginal involvement and/or parametrial involvement.d
IIICb Metastases to pelvic and/or para-aortic lymph nodes.d
IIIC1b Positive pelvic nodes.
IIIC2b Positive para-aortic nodes with or without positive pelvic lymph nodes.
IVb Tumor invades bladder and/or bowel mucosa, and/or distant metastases.
IVAb Tumor invasion of bladder and/or bowel mucosa.
IVBb Distant metastasis, including intra-abdominal metastases and/or inguinal nodes.

Even if it no longer influences staging, retrospective data based on the Surveillance, Epidemiology, and End Results Program suggest that positive peritoneal cytology is an independent risk factor in patients with early-stage endometrial cancer.[3]

References

  1. FIGO Committee on Gynecologic Oncology: FIGO staging for carcinoma of the vulva, cervix, and corpus uteri. Int J Gynaecol Obstet 125 (2): 97-8, 2014. [PUBMED Abstract]
  2. Corpus uteri. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 403-18.
  3. Garg G, Gao F, Wright JD, et al.: Positive peritoneal cytology is an independent risk-factor in early stage endometrial cancer. Gynecol Oncol 128 (1): 77-82, 2013. [PUBMED Abstract]
  • Updated: April 17, 2015