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Gastrointestinal Carcinoid Tumors Treatment (PDQ®)

  • Updated: 02/28/2014

Table 1. Gastrointestinal Neuroendocrine Cellsa

Cell Type Location Secretory Product
G cellGastric antrum and duodenumGastrin
ECL cellGastric fundus and bodyHistamine
D cellStomach, duodenum, jejunum, colon, and rectumSomatostatin
EC cellStomach, duodenum, jejunum, ileum, colon, and rectumSerotonin, motilin, and substance P
CCK cellDuodenum and jejunumCholecystokinin
GIP cellDuodenum and jejunumGastric inhibitory polypeptide
M cellDuodenum and jejunumMotilin
S cellDuodenum and jejunumSecretin
PP cellDuodenumPancreatic polypeptide
L cellJejunum, ileum, colon, and rectumPolypeptide YY
N cellJejunum and ileumNeurotensin

CCK = cholecystokinin; D = somatostatin-producing; EC = enterochromaffin; ECL = enterochromaffin-like; G = Gastrin cell; GIP = gastric inhibitory polypeptide; L = enteroendocrine; M = motilin; N = neurotensin; PP = pancreatic polypeptide; S = secretin.
a Adapted from [1-3]

References

  1. Levy AD, Sobin LH: From the archives of the AFIP: Gastrointestinal carcinoids: imaging features with clinicopathologic comparison. Radiographics 27 (1): 237-57, 2007 Jan-Feb.  [PUBMED Abstract]

  2. Burke AP, Thomas RM, Elsayed AM, et al.: Carcinoids of the jejunum and ileum: an immunohistochemical and clinicopathologic study of 167 cases. Cancer 79 (6): 1086-93, 1997.  [PUBMED Abstract]