Treatment depends on the:

• Cell type.
• Stage.
• Level of serum Beta-human chorionic gonadotrophin (BhCG).
• Duration of the disease.
• Specific sites of metastasis.
• Extent of prior treatment.

Of utmost importance in treating patients with gestational trophoblastic tumors is instituting therapy as quickly as possible and continuing chemotherapy at very close intervals until normal BhCG titers are obtained. The interval between courses should rarely exceed 14 to 21 days depending on the treatment. It is recommended that patients receive one to three courses of chemotherapy after the first normal BhCG titer, depending on the extent of disease. Regardless of stage, if one of the high-risk factors is present, the patient should be treated with combination chemotherapy.