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Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment (PDQ®)

Health Professional Version

Cellular Classification of Pancreatic Neuroendocrine Tumors (Islet Cell Tumors)

Table 1. Endocrine Tumors of the Pancreas
Islet CellsSecreted Active AgentTumor and Syndrome
ACTH = adrenocorticotropin; MSH = melanocyte-stimulating hormone; VIP = vasoactive intestinal peptide; WDHA = watery diarrhea, hypokalemia, and achlorhydria; 5-HT = serotonin.
AlphaGlucagonGlucagonoma (diabetes, dermatitis)
BetaInsulinInsulinoma (hypoglycemia)
DeltaSomatostatinSomatostatinoma (mild diabetes); diarrhea/steatorrhea; gallstones
DGastrinGastrinoma (peptic ulcer disease)
A -> DVIP and/or other undefined mediatorsWDHA
5-HT
ACTH
MSHCarcinoid
Cushing syndrome
Hyperpigmentation
Interacinar Cells Secreted Active Agent Tumor and Syndrome
FPancreatic polypeptideMultiple hormonal syndromes
EC5-HTCarcinoid
  • Updated: March 7, 2014