Last Modified: 06/29/2012
Cellular Classification of Pancreatic Neuroendocrine Tumors (Islet Cell Tumors)
Table 1. Endocrine Tumors of the Pancreas
| Islet Cells | Secreted Active Agent | Tumor and Syndrome |
| ACTH = adrenocorticotropin; MSH = melanocyte-stimulating hormone; VIP = vasoactive intestinal peptide; WDHA = watery diarrhea, hypokalemia, and achlorhydria; 5-HT = serotonin. | ||
| Alpha | Glucagon | Glucagonoma (diabetes, dermatitis) |
| Beta | Insulin | Insulinoma (hypoglycemia) |
| Delta | Somatostatin | Somatostatinoma (mild diabetes); diarrhea/steatorrhea; gallstones |
| D | Gastrin | Gastrinoma (peptic ulcer disease) |
| A -> D | VIP and/or other undefined mediators | WDHA |
| 5-HT | ||
| ACTH | ||
| MSH | Carcinoid | |
| Cushing syndrome | ||
| Hyperpigmentation | ||
| Interacinar Cells | Secreted Active Agent | Tumor and Syndrome |
| F | Pancreatic polypeptide | Multiple hormonal syndromes |
| EC | 5-HT | Carcinoid |