The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Advanced Malignant Mesothelioma (Stages II, III, and IV)

Added text about a randomized phase III trial that compared cisplatin alone with the combination of raltitrexed and cisplatin in first-line treatment of patients with malignant pleural mesothelioma (cited van Meerbeeck et al. as reference 19 and level of evidence 1iiA).

Recurrent Malignant Mesothelioma

Added Zucali et al. as reference 3. Added text to state that patients with recurrent mesothelioma but without prior chemotherapy are candidates for first-line chemotherapy with cisplatin pemetrexed or cisplatin raltitrexed; patients who receive surgery without chemotherapy and recur are candidates for chemotherapy.

Added text about a study that compared pemetrexed to best supportive care in patients who received one prior regimen of chemotherapy without pemetrexed (cited Jassem et al. as reference 6 and level of evidence 1iiA).

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