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Merkel Cell Carcinoma Treatment (PDQ®)

  • Updated: 03/07/2014

Table 4. Regional Lymph Nodes (N)a

NXRegional lymph nodes cannot be assessed.
N0No regional lymph nodes metastasis.
cN0Nodes negative by clinical examb (no pathologic node exam performed).
pN0Nodes negative by pathologic exam.
N1Metastases in regional lymph node(s).
N1aMicrometastasis.c
N1bMacrometastasis.d
N2In transit metastasis.e

aReprinted with permission from AJCC: Merkel cell carcinoma. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 315-23.
bClinical detection of nodal disease may be via inspection, palpation, and/or imaging.
cMicrometastases are diagnosed after sentinel or elective lymphadenectomy.
dMacrometastases are defined as clinically detectable nodal metastases confirmed by therapeutic lymphadenectomy or needle biopsy.
eIn transit metastasis: a tumor distinct from the primary lesion and located either (1) between the primary lesion and the draining regional lymph nodes or (2) distal to the primary lesion.