Changes to This Summary (05/30/2013)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Added text to state that a substantial number of patients are ineligible for standard surgical resection because of comorbid conditions that are associated with unacceptably high perioperative risk; observation and radiation therapy may be considered for these patients (cited McGarry et al., Lanni et al., and Grutterset al. as reference 22, reference 23, and reference 24, respectively). Also added text to state that nonrandomized observation studies comparing treatment outcomes associated with resection, radiation therapy, and observation have demonstrated shorter survival times and higher mortality for patients treated with observation only, there are a number of approaches to delivery of radiation therapy, and there are limited reliable data from comparative trials to determine which yield superior outcomes.
Added Curran et al as reference 35.
This summary is written and maintained by the PDQ Adult Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.