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Ovarian Germ Cell Tumors Treatment (PDQ®)

Treatment Option Overview

Standard treatment options for patients with ovarian germ cell tumors include:

  • Surgery.
  • Chemotherapy.
  • Radiation therapy.

Patients may be treated with unilateral salpingo-oophorectomy or total abdominal hysterectomy and bilateral salpingo-oophorectomy.

All patients except those with stage I, grade I immature teratoma and stage IA dysgerminoma require postoperative chemotherapy. With platinum-based combination chemotherapy, the prognosis for patients with endodermal sinus tumors, immature teratomas, embryonal carcinomas, choriocarcinomas, and mixed tumors containing one or more of these elements has improved dramatically.[1] As new and more effective drugs are developed, many of these patients will be candidates for newer clinical trials.

Treatment options under clinical evaluation for patients with ovarian germ cell tumors include:

  • High-dose chemotherapy with bone marrow transplant.
  • New treatment options.

References

  1. Gershenson DM, Morris M, Cangir A, et al.: Treatment of malignant germ cell tumors of the ovary with bleomycin, etoposide, and cisplatin. J Clin Oncol 8 (4): 715-20, 1990. [PUBMED Abstract]
  • Updated: March 7, 2014