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Small Cell Lung Cancer Treatment (PDQ®)

Health Professional Version

Changes to This Summary (01/23/2015)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

General Information About Small Cell Lung Cancer (SCLC)

Updated statistics with estimated new cases and deaths for 2015 (cited American Cancer Society as reference 3).

Added text to state that thoracic radiation may also improve long-term outcomes for patients with extensive-stage disease (cited Slotman et al. as reference 18).

Treatment Option Overview for SCLC

Added Slotman et al. as reference 16.

Revised text to state that prophylactic cranial radiation prevents central nervous system recurrence and may improve the long-term survival of patients with good performance status who have responded to chemoradiation therapy.

Limited-Stage SCLC Treatment

Added Kubota et al. as reference 16.

Revised text to state that administration of additional drugs or other (non–etoposide-containing) platinum-based combination regimens did not result in any consistent survival benefit.

Added Salama et al., Choi et al., Miller et al., and Kelley et al. as references 22, 23, 24, and 25, respectively.

Extensive-Stage SCLC Treatment

Added text to the standard treatment options to include thoracic radiation therapy for patients who respond to chemotherapy.

Added Thoracic radiation therapy for patients who respond to chemotherapy as a new subsection.

Added text to state that only 29% of the randomly assigned patients had brain imaging at diagnosis (cited Shivnani as reference 44).

This summary is written and maintained by the PDQ Adult Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.

  • Updated: January 23, 2015