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Vulvar Cancer Treatment (PDQ®)

Health Professional Version
Last Modified: 03/12/2014

Cellular Classification of Vulvar Cancer

Presented below is an adaptation of the histologic classification of vulvar disease and precursor lesions of cancer of the vulva developed by the International Society for the Study of Vulvar Disease.[1] This evidence summary deals with vulvar intraepithelial neoplasias (VIN) and invasive carcinomas.

Non-neoplastic epithelial disorders of skin and mucosa

  • Lichen sclerosus (lichen sclerosus et atrophicus).
  • Squamous cell hyperplasia (formerly hyperplastic dystrophy).
  • Other dermatoses.

VIN

  • Usual type (high-grade 2 and 3).
  • Differentiated type (high-grade 3).

Paget disease of the vulva

  • Characteristic large pale cells in the epithelium and skin adnexa.

Other histologies

  • Basal cell carcinoma.
  • Histiocytosis X.
  • Malignant melanoma.
  • Sarcoma.
  • Verrucous carcinoma.
References
  1. Sideri M, Jones RW, Wilkinson EJ, et al.: Squamous vulvar intraepithelial neoplasia: 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee. J Reprod Med 50 (11): 807-10, 2005.  [PUBMED Abstract]