Childhood Cancers

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Children with Cancer: A Guide for Parents

Practical information about treatment, coping and support, health issues, and more. Take a look!

A cancer diagnosis is upsetting at any age, but especially so when the patient is a child. It’s natural to have many questions, such as, Who should treat my child? Will my child get well? What does all of this mean for our family? Not all questions have answers, but the information and resources on this page provide a starting point for understanding the basics of childhood cancer.

Treating Childhood Cancer

Children's cancers are not always treated like adult cancers. Pediatric oncology is a medical specialty focused on the care of children with cancer. It's important to know that this expertise exists and that there are effective treatments for many childhood cancers.

Where Children with Cancer Are Treated

Children who have cancer are often treated at a children’s cancer center, which is a hospital or unit in a hospital that specializes in treating children with cancer. Most children’s cancer centers treat patients up to age 20.

The doctors and other health professionals at these centers have special training and expertise to give complete care to children. Specialists at a children’s cancer center are likely to include primary care physicians, pediatric medical oncologists/hematologists, pediatric surgical specialists, radiation oncologists, rehabilitation specialists, pediatric nurse specialists, social workers, and psychologists. At these centers, clinical trials are available for most types of cancer that occur in children, and the opportunity to participate in a trial is offered to many patients.

At the National Institutes of Health’s Clinical Center in Bethesda, Maryland, NCI’s Pediatric Oncology Branch cares for children with cancer. Health professionals and scientists conduct translational research that spans basic science to clinical trials to improve outcomes for children and young adults with cancer and genetic tumor predisposition syndromes.

Types of Treatment

There are many types of cancer treatment. The types of treatment that a child with cancer receives will depend on the type of cancer and how advanced it is. Common treatments include: surgery, chemotherapy, radiation therapy, immunotherapy, and stem cell transplant. Learn about these and other therapies in our Types of Treatment section.

NCI’s PDQ® pediatric treatment cancer information summaries explain treatment options for all children’s cancers. The summaries also include information about diagnosing and staging cancer.

Clinical Trials

Before any new treatment can be made widely available to patients, it must be studied in clinical trials (research studies) and found to be safe and effective in treating disease. Clinical trials for children and adolescents with cancer are generally designed to compare potentially better therapy with therapy that is currently accepted as standard. Most of the progress made in identifying curative therapies for childhood cancers has been achieved through clinical trials.

Our site has information about how clinical trials work. Information specialists who staff NCI’s Cancer Information Service can answer questions about the process and help identify ongoing clinical trials for children with cancer.

Treatment Effects

Children face unique issues during their treatment for cancer, after the completion of treatment, and as survivors of cancer. For example, they may receive more intense treatments, cancer and its treatments have different effects on growing bodies than adult bodies, and they may respond differently to drugs that control symptoms in adults. For more information, see the PDQ® Pediatric Supportive Care summary.

All cancer survivors can develop health problems months or years after cancer treatment, known as late effects. For childhood cancer survivors, late effects are of particular concern because these may last for many years. To learn about factors that may contribute to late effects (both physical and emotional), different types that occur, and ways to manage them, see the PDQ® Late Effects of Treatment for Childhood Cancer summary.

Coping with Cancer

Our Coping with Cancer section contains information on how to adjust to a cancer diagnosis in the family and take practical steps to manage many of your concerns.

Types of Cancer in Children

In the United States in 2015, an estimated 10,380 new cases of cancer will be diagnosed among children from birth to 14 years, and more than 1,000 children will die from the disease. Although pediatric cancer death rates have declined by nearly 70 percent over the past four decades, cancer remains the leading cause of death from disease among children. The major types of cancers in children ages 0 to14 years are acute lymphocytic leukemia (ALL), brain and other central nervous system (CNS) tumors, and neuroblastoma, which are expected to account for more than half of new cases in 2015.

Cancer Causes

The causes of most childhood cancers are not known. About 5 percent of all cancers in children are caused by an inherited mutation (a genetic mutation that can be passed from parents to their children).

Most cancers in children, like those in adults, are thought to develop as a result of mutations in genes that lead to uncontrolled cell growth and eventually cancer. In adults, these gene mutations reflect the cumulative effects of aging and long-term exposure to cancer-causing substances. However, identifying potential environmental causes of childhood cancer has been difficult, partly because cancer in children is rare and partly because it is difficult to determine what children might have been exposed to early in their development. More information about possible causes of cancer in children is available in the fact sheet, Cancer in Children and Adolescents.


NCI supports a broad range of research to better understand the causes, biology, and patterns of childhood cancers and to identify the best ways to successfully treat children with cancer. In the context of clinical trials, researchers are treating and learning from young cancer patients. Researchers are also following childhood cancer survivors to learn about health and other issues they may face as a result of their cancer treatment. To learn more, see Childhood Cancers Research.