Changes to This Summary (10/30/2013)
Revised text to state that the studies that have been published consist of randomized controlled trials, anecdotal reports, case reports, case series, and uncontrolled clinical studies (cited Lesser et al. as reference 8).
Added text about a randomized trial of 20 patients that tested the ability of coenzyme Q10 to reduce cardiotoxicity caused by anthracycline drugs; a larger randomized, placebo-controlled trial of 236 breast cancer patients concluded that coenzyme Q10 at a daily dose of 300 mg combined with 300 IU of vitamin E, divided into three doses, did not improve fatigue levels or quality of life after 24 weeks of supplementation.
This summary is written and maintained by the PDQ Cancer Complementary and Alternative Medicine Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.