Changes to This Summary (11/12/2014)
Added text to state that in follow-up, silymarin use was associated with reduced progression of fibrosis to cirrhosis but without an impact on clinical outcome (cited Freedman et al. as reference 15).
Added text state that patients in a phase I pharmacokinetics study for the evaluation of absorption characteristics and determination of effective doses received increasing oral doses of silymarin; a subsequent multicenter, double-blind, placebo-controlled trial, involving 154 patients with chronic hepatitis C virus infection who had previously failed interferon-based treatment and had raised alanine aminotransferase (ALT) levels, found that silymarin given orally in higher-than-usual doses failed to significantly reduce serum ALT levels and that no significant adverse effects were associated with silymarin (cited Hawke et al. as reference 19 and Fried et al. as reference 20).
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