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Mistletoe Extracts (PDQ®)

Health Professional Version

Changes to This Summary (01/13/2015)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

General Information

Added text to state that Eurixor, Isorel, and Vysorel are no longer available on the market for sale.

Laboratory/Animal/Preclinical Studies

Added text to state that in this in vitro study, mistletoe did not inhibit chemotherapy-induced cytostasis or cytotoxicity (cited Weissenstein et al. as reference 60).

Human/Clinical Studies

Added text to state that Eurixor, Isorel, and Vysorel are no longer available on the market for sale.

Added text about an interim analysis of a randomized phase III trial that reported on 220 patients with locally advanced or metastatic pancreatic cancer in whom treatment with Iscador demonstrated a significant enhancement of overall survival (cited Tröger et al. as reference 23).

Added text about a subgroup analysis that demonstrated clinically relevant enhancement in the survival of both groups of patients who received Iscador; for patients who received Iscador, the frequency and severity of post baseline disease-related symptoms were also significantly lower for pain, weight loss, fatigue, nausea and/or emesis, diarrhea, and anxiety.

Added text to state that the independent data monitoring committee that reviewed the interim analysis results recommended termination of the trial because of statistically significant superiority of survival in the treatment group as compared with the control group.

Revised text to state that the interferon injections were administered every other day, whereas IscadorM was administered 3 times a week for up to 1 year.

Added text to Table 1 about a randomized trial that found that treatment with Iscador improved survival in patients with advanced or metastatic pancreatic cancer.

Added text to state that Eurixor is no longer available on the market for sale.

Added text to state that Isorel is no longer available on the market for sale.

This summary is written and maintained by the PDQ Cancer Complementary and Alternative Medicine Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.

  • Updated: January 13, 2015