Table 15. Summary of Studies Evaluating Attitudes Toward, Interest in, or Intention to Use Assisted Reproductive Technology (ART) for FAPa, LSb, and PJSa
| Study Population | Nc | Interest or Intention in ART | Comments |
| FAP-affected individuals [27] | 20 | 95% would consider prenatal GT for FAP; 90% would consider PGD; 75% would consider amniocentesis or chorionic villous sampling | |
| FAP-affected individuals [20] | 341 | 33% would consider PND for FAP; 30% would consider PGD; 15% felt terminating pregnancy for FAP was acceptable | 24% and 25% of patients did not respond to questions about attitudes toward PND and PGD, respectively. |
| Individuals undergoing genetic testing for LS [29] | 48d | 21% would consider PND and/or PGD; 19% would consider only PND; 2% would consider only PGD | At 1 year after disclosure of GT results, two of nine mutation carriers reported that they were considering PGD for future pregnancy. |
| PJS-affected individualsa [30] | 52 | 15% indicated that pregnancy termination was acceptable if PND identified a fetus with PJS; 52% indicated PGD was acceptable for persons with PJS | Ten (19%) individuals, nine of whom were female, reported that they had decided not to conceive a child because of PJS. |
| FAP = familial adenomatous polyposis; GT = genetic testing; LS = Lynch syndrome; PGD = preimplantation genetic diagnosis; PJS = Peutz-Jeghers syndrome; PND = prenatal diagnosis. | |||
| aStudies used a cross-sectional design and were conducted in the United States,[27] and in the Netherlands.[20,30]. | |||
| bParticipants were invited to complete questionnaires before clinical genetic testing for LS and at 3 months and 1 year after disclosure of genetic test results. | |||
| cIndicates number of participants older than 18 y, unless otherwise specified. | |||
| dRepresents the number who indicated that they were considering having children in the future, out of a total of 130 individuals who answered a questionnaire prior to genetic testing [29]. |
References
- Douma KF, Aaronson NK, Vasen HF, et al.: Attitudes toward genetic testing in childhood and reproductive decision-making for familial adenomatous polyposis. Eur J Hum Genet 18 (2): 186-93, 2010. [PUBMED Abstract]
- Kastrinos F, Stoffel EM, Balmaña J, et al.: Attitudes toward prenatal genetic testing in patients with familial adenomatous polyposis. Am J Gastroenterol 102 (6): 1284-90, 2007. [PUBMED Abstract]
- Dewanwala A, Chittenden A, Rosenblatt M, et al.: Attitudes toward childbearing and prenatal testing in individuals undergoing genetic testing for Lynch syndrome. Fam Cancer 10 (3): 549-56, 2011. [PUBMED Abstract]
- van Lier MG, Korsse SE, Mathus-Vliegen EM, et al.: Peutz-Jeghers syndrome and family planning: the attitude towards prenatal diagnosis and pre-implantation genetic diagnosis. Eur J Hum Genet 20 (2): 236-9, 2012. [PUBMED Abstract]
