The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Constipation ¹

Added text ² to state that for children, the number of grams of fiber per day should equal age plus 5, until age 18 years; at that time, the adult recommendations should be followed.

Added text ³ to state that a study of prolonged-released naloxone in an oxycodone:naloxone ratio of 2:1 (average results of 40:20 mg, 60:30 mg, and 80:40 mg oxycodone:naloxone combination relative to placebo) demonstrated improved bowel function without reversal of analgesia (cited Meissner et al. as reference 8).