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Breast Cancer Treatment (PDQ®)

  • Updated: 07/11/2014

Table 6. Standard Adjuvant Chemotherapy Regimens for Stage I, II, IIIA, and Operable IIIC HER2/neu Non-Overexpressing Breast Cancer

Regimen Cycle Number and Duration (d) Cytoxan (mg/m²) 5-FU (mg/m²) Doxorubicin (mg/m²) Paclitaxel/Docetaxel (mg/m²) 
AC = cyclophosphamide, doxorubicin; AC-T = cyclophosphamide, doxorubicin, taxol; CAF = cyclophosphamide, doxorubicin, fluorouracil; d = day; D = docetaxel; IV = intravenously; P = paclitaxel; T = taxol; TAC = docetaxel, doxorubicin and cyclophosphamide; TC = docetaxel and cyclophosphamide; 5-FU = fluorouracil.
CAF [163]6 × 21500, IV d 1500, IV d 150, IV d 1
AC [166]4 × 21600, IV d 160, IV d 1
Dose-dense AC-T [179]4 (AC), 4 (T) ×14600, IV d 160, IV d 1P: 175, IV d 1
TAC [193, 194]6 × 21500, IV d 150, IV d 1D: 75, IV d 1
TC [195]4 x 21600, IV d 1D: 75, IV d 1