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Breast Cancer Treatment (PDQ®)

  • Updated: 11/14/2014

Table 6. Anatomic Stage/Prognostic Groupsa,b

Stage T N M Illustration  
0TisN0M0
IAT1bN0M0
IBT0N1miM0
T1bN1miM0
IIAT0N1cM0
T1bN1cM0
T2N0M0
IIBT2N1M0
T3N0M0
IIIAT0N2M0
T1bN2M0
T2N2M0
T3N1M0
T3N2M0
IIIBT4N0M0
T4N1M0
T4N2M0
IIICAny TN3M0
IVAny TAny NM1

aReprinted with permission from AJCC: Breast. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 347-76.
bT1 includes T1mi.
cT0 and T1 tumors with nodal micrometastases only are excluded from Stage IIA and are classified Stage IB.
–M0 includes M0(i+).
–The designation pM0 is not valid; any M0 should be clinical.
–If a patient presents with M1 prior to neoadjuvant systemic therapy, the stage is considered Stage IV and remains Stage IV regardless of response to neoadjuvant therapy.
–Stage designation may be changed if postsurgical imaging studies reveal the presence of distant metastases, provided that the studies are carried out within 4 months of diagnosis in the absence of disease progression and provided that the patient has not received neoadjuvant therapy.
–Postneoadjuvant therapy is designated with "yc" or "yp" prefix. No stage group is assigned if there is a complete pathologic response (CR) to neoadjuvant therapy, for example, ypT0ypN0cM0.