Histopathologic Classification of Breast Cancer
Table 1 describes the histologic classification of breast cancer based on tumor location. Infiltrating or invasive ductal cancer is the most common breast cancer histologic type and comprises 70% to 80% of all cases.
|Tumor Location||Histologic Subtype|
|NOS = not otherwise specified.|
|Ductal||Intraductal (in situ)|
|Invasive with predominant component|
|Medullary with lymphocytic infiltrate|
|Lobular||Invasive with predominant in situ component|
|Nipple||Paget disease, NOS|
|Paget disease with intraductal carcinoma|
|Paget disease with invasive ductal carcinoma|
The following tumor subtypes occur in the breast but are not considered typical breast cancers:
- Breast. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 347-76.
- Yeatman TJ, Cantor AB, Smith TJ, et al.: Tumor biology of infiltrating lobular carcinoma. Implications for management. Ann Surg 222 (4): 549-59; discussion 559-61, 1995. [PUBMED Abstract]
- Chaney AW, Pollack A, McNeese MD, et al.: Primary treatment of cystosarcoma phyllodes of the breast. Cancer 89 (7): 1502-11, 2000. [PUBMED Abstract]
- Carter BA, Page DL: Phyllodes tumor of the breast: local recurrence versus metastatic capacity. Hum Pathol 35 (9): 1051-2, 2004. [PUBMED Abstract]